Howard: Engage them for a minute and take note of their reactions.
Leonard: There's something familiar about all this.
Howard: Okay, go.
Sheldon: Hello, baby. Are you having a pleasant day?
Leonard: Oh, my G-- This is my entire childhood.
Sheldon: Leonard, Leonard, you're tainting my data.
Leonard: Uh, it's like word for word.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Stuart: Where are the kids?
Howard: I thought they were with you.
Stuart: What? No!
Howard: I'm kidding. They're at daycare.
Stuart: What about me makes you think my heart can handle that joke?

Leonard: Just tell me the truth, Mother. Was my whole childhood just one big experiment?
Beverly Hofstadter: Of course not, dear. It was thousands of small experiments.
Leonard: So that's all I was to you, a-a test subject?
Beverly Hofstadter: No, you were my baby and I found you fascinating.
Leonard: Really?
Beverly Hofstadter: Yes, watching you develop, tracking your progress. I know I'm not the warmest of parents, but it was time we spent together, and, honestly, those are some of my fondest memories.
Leonard: When did you stop?
Beverly Hofstadter: Oh, I can't tell you. The experiment isn't over.

Raj: I never thought I would see Sheldon enjoying himself around babies so much.
Amy: Yeah, how about that?
Raj: So he just happened to stumble upon a book about experimenting with them the same day we were hanging out with Howard's kids?
Amy: Yep, don't overthink it.