Leonard: How you feeling about it?
Raj: Uh, to be honest, I'm pretty anxious. I mean, this is the woman I'm marrying. What if it's no good? Do we break up? Do we sign on for a lifetime of mediocre sex?
Leonard: Just don't put so much pressure on it. It's always a little awkward in the beginning. I remember the first time I slept with Penny.
Raj: It was bad?
Leonard: Oh, it was awesome! I will replay it in my head until the day I die.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Sheldon: So the doctor prescribed Nizoral and it blocked enzyme action, and the fungus cleared right up.
Mrs. Fowler: That's a very disturbing picture.
Sheldon: Yes, well, they say a picture's worth a thousand words, but I say nothing beats a picture and a thousand words.
Mrs. Fowler: Still, you might want to take it off Facebook.
Sheldon: Oh, no. It's in my nature to share.

Mrs. Fowler: I don't know about you, but I don't really like magic.
Sheldon: You just keep getting better and better.

Howard: Hey, have you checked the dates on these? They're all expired.
Stuart: You buy candy in a comic book store, you get what you get.