Leonard: Maybe it is a little like Penny. Any chance she'll be flattered?
Bernadette: I don't know. She's pretty mean.
Leonard: Ilsa or Penny?
Bernadette: Exactly.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Amy: So, you're just gonna sit here by yourself and do nothing?
Sheldon: Of course not. I'm going to write mean comments about Wil's show online.
Amy: Well, you can't criticize something you haven't seen.
Sheldon: I'm sorry, are you familiar with the Internet?

Sheldon: Oh, Amy. Good, you're here.
Amy: Hi. What's up?
Sheldon: How would you like to be on television?
Amy: Is it gonna be a news story where I have to say you were quiet and kept to yourself and I'm as shocked as anyone?

Wil Wheaton: [on TV] It's time for Professor Proton's science joke of the day. Why can you not trust atoms?
Sheldon: Hmm.
Wil Wheaton: [on TV] Because they make up everything.
Sheldon: Oh, that's funny! Yeah, because they do. They make up everything.