Sheldon: Well, I don't need you to pretend to be okay for me. If anything, that makes it worse.
Amy: Fine. I'm not okay. We came up with this idea at our wedding. We poured months of our lives into it. I thought we were changing the course of science, and now it's all gone. I'm devastated.
Sheldon: I was wrong, that makes it worse. Go back to being happy.