Quote from The Good Son
Niles: Of course, I can't take care of him.
Frasier: Oh, yes, of course. Of course. Why?
Niles: Because Dad doesn't get along with Maris.
Frasier: Who does?
Niles: I thought you liked my Maris.
Frasier: I do. I like her from a distance. You know, the way you like the sun. Maris is like the sun, except without the warmth.
Quote from She's the Boss
Frasier: What the hell was that? Was that a gunshot?
Niles: Morning, Frasier. Just getting up?
Frasier: "Just getting up?" Are you out of your mind? A gun just went off in here!
Martin: Niles bought a starter's pistol.
Niles: And there's no need to get snippy. Accidents happen, you know.
Frasier: Oh, I'm sorry. Was I snippy? I didn't realize it was too much to ask that there not be gunplay in my living room!
Quote from Frasier's Curse
Frasier: Just read it. Scott Alexander, what's he been up to?
Daphne: Wife, kids, has his own computer software business.
Frasier: Nancy Kearns.
Daphne: Mother of three, successful physician, has invented a drug that may aid in the treatment of cancer.
Frasier: Ah, a cure for cancer. Won't they be green with envy when I trump them all with this little story of my life: Frasier Crane, unattached, unemployed and living with his father. He spends his days scrubbing his oven and is anxiously awaiting his upcoming tooth cleaning!
Quote from She's the Boss
Martin: Look at him, he's humiliated!
[A dog barks from the apartment above]
Daphne: Yeah, well, it doesn't help that that bully upstairs keeps rubbing it in.
[Eddie barks towards the ceiling]
Martin: You tell him, boy!
[Frasier emerges from his bedroom in his dressing gown]
Frasier: Oh, for God's sake, I am trying to get some sleep. I asked you to keep that dog quiet, and instead you outfit him with a megaphone!
Quote from You Can Go Home Again
Frasier: Are you trying to get transferred?
Roz: Look, Dr. Crane, I got to be honest with you here. It's just that I-I think psychiatry is, just, sort of, kind of ... bull.
Frasier: Oh, well, this is a match made in heaven then, isn't it?!
Roz: Oh, don't be offended.
Frasier: "Don't be offended." Why should I be offended? In the last week, I've uprooted myself from my home of fifteen years, moved all the way across the country away from everything I care about, and plunged myself into a frightening new career. The first few nerve-wracking moments, I walk in here and find my producer lobbying to get herself transferred to another show. Abe Lincoln had a brighter future when he picked up his tickets at the box office!
Quote from Murder Most Maris
Niles: Oh, well, I'm- I'm stunned of course. The idea that Maris actually killed someone.
Frasier: Well, we've all seen her murder many a lively dinner party.
Martin: That's terrible.
Frasier: Oh, come on, I'm joking. And haven't I earned the right to my gallows humor? After all, are you forgetting that just this afternoon I was punched in the face by a man now dead?
Quote from Don Juan in Hell (Part 2)
Frasier: So that's it? All this work, just to find out that I have a fear of rejection?
Lilith: That's right.
Frasier: So I'm alone... because I'm afraid to be alone?!
Quote from We Two Kings
Niles: Why do you have to make everything so difficult?
Frasier: Excuse me, Niles, but I’ve got news for you. Copernicus called, and you are not the center of the universe!
Quote from Caught in the Act
Frasier: Dear God! Have we lost our minds?
Nanette: Frasier, do you know how bored I am being "Nanny G." How trapped I feel...
Frasier: You have a wonderful career.
Nanette: But nothing ever changes. Do you have any idea what it's like to play the same character for twenty years?
Quote from IQ
Frasier: Daphne, is that university library open all night?
Daphne: I think so, why do you ask?
Frasier: Oh, for God's sake. Do you think I'm going to let my little brother humiliate me tomorrow?
Martin: What are you talking about?
Frasier: Dad, he is smarter than I am. Niles will be sitting there rambling on to the geniuses about the cosmos, black holes, matter, antimatter, and I won't matter at all.